Congenital Heart Disease Enalapril in Infants With Single Ventricle Results of a Multicenter Randomized Trial
نویسندگان
چکیده
Daphne T. Hsu, MD; Victor Zak, PhD; Lynn Mahony, MD; Lynn A. Sleeper, ScD; Andrew M. Atz, MD; Jami C. Levine, MD; Piers C. Barker, MD; Chitra Ravishankar, MD; Brian W. McCrindle, MD; Richard V. Williams, MD; Karen Altmann, MD; Nancy S. Ghanayem, MD; Renee Margossian, MD; Wendy K. Chung, MD; William L. Border, MBChB, MPH; Gail D. Pearson, MD, ScD; Mario P. Stylianou, PhD; Seema Mital, MD; for the Pediatric Heart Network Investigators
منابع مشابه
Enalapril in infants with single ventricle: results of a multicenter randomized trial.
BACKGROUND Angiotensin-converting enzyme inhibitor therapy improves clinical outcome and ventricular function in adults with heart failure. Infants with single-ventricle physiology have poor growth and are at risk for abnormalities in ventricular systolic and diastolic function. The ability of angiotensin-converting enzyme inhibitor therapy to preserve ventricular function and improve somatic g...
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BACKGROUND We investigated the effect of polymorphisms in the renin-angiotensin-aldosterone system (RAAS) genes on ventricular remodeling, growth, renal function, and response to enalapril in infants with single ventricle. METHODS AND RESULTS Single ventricle infants enrolled in a randomized trial of enalapril were genotyped for polymorphisms in 5 genes: angiotensinogen, angiotensin-convertin...
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